Endocrine Abstracts

Aim: Gallstones are associated with excess body fat. Our aim was to evaluate lipid levels and markers of oxidative stress in subjects with asymptomatic gallstones.Material and method: Eighty subjects (55 females, 25 males) with a mean age±S.D. of 51±14 years with asymptomatic gallstones were admitted to the study. Forty subjects (25 females, 15 males) with a mean age±S.D. of 57±12 years (P<0....

Peudohypoparathyroidism is a heterogenous group of disorders characterized by hypocalcemia, hyperphosphatemia, increased serum concentration of parathormone, and insensivity to biological activity of parathormone.A 45-year-old female was admitted to the regional hospital for check up and routine laboratory studies revealed slightly decreased level of calcium. Her neurologic examination was negative for Chvostek’s and Trousseau’ signs. Laborator...

Introduction: It is well known association between cardiovascular disease and PCOS. Approximately 17–43% of women with PCOS have hyperprolactinemia. Increased levels of prolactin often associated with an increased risk for thromboembolic events, but underline pathophisiological mechanism still unknown. The strong association between hyperprolactinemia and platelet aggregation is well known. Platelets play a key role in the development of atherothrombosis, a major contribu...

We report an 18 years old female with hepatomegaly and elevated liver function tests. She had been diagnosed with Type 1 diabetes mellitus when she was 13 years old. She was referred to our division because of diabetic ketoacidosis. Evaluation of her previous records revealed the presence of liver function abnormalities for 4 months. At physical examination she had an enlarged liver. A1c level was 13%. She was treated initially with intravenous insulin. Following the achieveme...

Previous gestational diabetes mellitus (pGDM) is associated with insulin resistance which is a well-known risk factor for atherosclerotic diseases. Mean platelet volume (MPV) is an indicator of platelet activation which plays a crucial role in pathogenesis of atherosclerosis.One hundred and five consecutive women with pGDM and 40 healthy women with normal previous pregnancies were included in the study. At the time of enrollment, anthropometric measureme...

It has been shown that women with previous GDM more likely developed metabolic syndrome (MS). This study aimed to determine predictors of the later development of MS in women with previous GDM.One hundred sixty-four consecutive women with previous GDM were evaluated after a mean follow-up of 40.54 months from index pregnancy. Sixty-five lean women with negative screening for GDM were included as a control group. Data regarding antenatal and peripartum ch...

Context: Irisin, a newly discovered hormone, is secreted by skeletal muscles into circulation. It is proposed to regulate energy homeostasis and hold therapeutic potential in diabetes and obesity.Objective: We aimed to investigate the association of irisin and uncoupling protein 1 (UCP1) with gestational diabetes mellitus (GDM).Design and Setting: This was a cross-sectional study conducted in a university hospital.<p class="abs...

Data regarding cardiovascular risk in subjects with non-functioning adrenal adenoma is limited. The aim of this study is to investigate osteoprotogerin (OPG) and Interleukin-6 (IL-6) levels in subjects with non functioning adrenal incidentalomas.Of 51 subjects without findings of hypercortisolism or other adrenal gland disorders (AI), 32 BMI-unmatched controls (C) and 20 BMI-matched controls (BC) were enrolled. Participants underwent hormonal evaluation ...

It has been previously shown that adrenal adenomas are associated with a variety of metabolic disturbances like glucose intolerance and obesity. The aim of this study is to demonstrate the risk of non-alcoholic fatty liver disease development in subjects with adrenal incidentalomas.Among 302 subjects referred between 2001 and 2008 for the evaluation of incidentally discovered adrenal mass, 150 subjects with appropriate data were included. Computed tomogr...

Adrenal adenomas are characterised with metabolic disturbances. The aim of this study is to demonstrate the changes in some metabolic and anthropometric parameters after 24 months follow up in subjects with non-functioning adrenal adenomas.Subjects referred between 2001 and 2008 for the evaluation of adrenal tumours were included. Computed tomography (CT) was the initial radiological intervention. Initial hormonal evaluation included 1 mg or 2 day 2 mg d...